Free PTCB practice · Updated October 2026

PTCB drug utilization review and allergy checks practice questions, with every answer explained

Patient Safety and Quality Assurance is 23.75% of the scored PTCE (the PTCB exam). Answer 10 exam style questions on drug utilization review and allergy checks and see exactly which concepts would cost you points on test day.

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Where the PTCE points areshare of 80 scored items
Medications
35%
Patient Safety and Quality Assurance
23.75%
Order Entry and Processing
22.5%
Federal Requirements
18.75%
Source: PTCE content outline, effective Jan 6, 2026You are here ↑
Score 0/0
Q1Technician vs pharmacist role

While picking up lisinopril, a patient asks the technician, "Is it OK to take ibuprofen with this?" What should the technician do?

What these drug utilization review and allergy checks questions test

These questions cover technician vs pharmacist role, drug utilization review and allergy checks. Each one shows the correct answer and why every other option is wrong, so a miss tells you exactly what to review before the PTCE.

Technician vs pharmacist roleDrug utilization reviewAllergy checks

All 10 questions with answers explained

Prefer to read first? Every question from the practice set above, with the correct answer and why each wrong option is wrong.

Q1While picking up lisinopril, a patient asks the technician, "Is it OK to take ibuprofen with this?" What should the technician do?
  1. Refer the question to the pharmacist
  2. Say OTC pain relievers are safe with any prescription
  3. Read the lisinopril package insert aloud to the patient
  4. Tell the patient to ask the doctor at the next visit

Answer: A. Questions about drug interactions require clinical judgment and are answered by the pharmacist. NSAIDs such as ibuprofen can reduce the effect of ACE inhibitors and affect kidney function, so the pharmacist needs to assess the patient.

Why not B: This is false and gives clinical advice a technician may not give.

Why not C: Interpreting drug information for a patient is counseling, which belongs to the pharmacist.

Why not D: The pharmacist is available now. Delaying the answer leaves the patient at risk in the meantime.

Exam tactic: Any "Is it safe...?" or "Should I...?" question goes to the pharmacist.

Q2A patient presents a new prescription for hydrocodone/acetaminophen. The previous 30-day supply was filled 12 days ago, and an early fill alert appears. What should the technician do?
  1. Fill it, because the patient says the pain got worse
  2. Bring the alert to the pharmacist
  3. Fill half the quantity to cover the patient until day 30
  4. Tell the patient the plan will pay for it after day 20

Answer: B. An early fill alert may signal overuse, misuse, or a dose change. With an opioid, the pharmacist must evaluate the situation before anything is filled. (Schedule II drugs such as hydrocodone combinations cannot be refilled, which is why a new prescription was needed.)

Why not A: The patient's explanation needs pharmacist evaluation. A technician cannot decide this.

Why not C: Partial fills to bypass an alert are not a technician decision and do not address the concern.

Why not D: The issue is clinical and legal, not only an insurance date.

Exam tactic: Early fill alert on an opioid = pharmacist, every time.

Q3A patient says, "Codeine makes me sick to my stomach," when asked about drug allergies. How should the technician handle this?
  1. Do not record it, since nausea is not an allergy
  2. Record codeine with nausea as the reaction
  3. Record it as a severe allergy to all opioids
  4. Record it as an allergy without listing the reaction

Answer: B. Recording the drug and the exact reaction lets the pharmacist tell an intolerance (such as nausea) from a true allergy (such as hives or swelling). The technician does not decide which it is.

Why not A: Deciding what counts as an allergy is clinical judgment, and unrecorded reactions are lost.

Why not C: This overstates the reaction and may block appropriate therapy.

Why not D: Without the reaction, the pharmacist cannot judge how serious it is.

Exam tactic: Record exactly what the patient reports. Let the pharmacist classify it.

Q4A prescription for oxycodone shows a quantity that appears changed from "10" to "40" in a different ink. What should the technician do?
  1. Fill 10 tablets, since that was the original amount
  2. Confront the patient and accuse them of altering it
  3. Notify the pharmacist privately before filling
  4. Fill 40 tablets, since the prescription shows 40

Answer: C. Different ink or altered numbers are signs of a possibly altered prescription. The pharmacist verifies it with the prescriber. The technician should not confront the patient.

Why not A: Guessing the original quantity is not a technician decision. The prescription must be verified.

Why not B: Confrontation can be unsafe and is not the technician's role. The pharmacist handles it.

Why not D: Filling an apparently altered controlled substance prescription without verification is a serious error.

Exam tactic: Signs of alteration = quiet alert to the pharmacist.

Q5A patient filling sertraline monthly presents a new prescription for escitalopram from a different prescriber. Which DUR alert is most likely to appear?
  1. Drug-allergy
  2. Early refill
  3. Drug-disease
  4. Therapeutic duplication

Answer: D. Sertraline and escitalopram are both SSRIs. Two drugs from the same class for the same purpose trigger a therapeutic duplication alert, which the pharmacist must review.

Why not A: Nothing indicates an allergy to either drug.

Why not B: Escitalopram is a new prescription, not a refill of sertraline.

Why not C: There is no disease state here that conflicts with escitalopram. The problem is two SSRIs.

Exam tactic: Two drugs, same class, same purpose = therapeutic duplication.

Q6A patient's profile shows "NKDA" from 3 years ago. The patient presents a new prescription. What should the technician do?
  1. Nothing, because NKDA never needs to be updated
  2. Ask whether any new drug allergies have developed
  3. Enter a penicillin allergy as a safety precaution
  4. Ask the prescriber's office for the patient's allergies

Answer: B. NKDA means no known drug allergies, but allergy status can change. Allergy information should be confirmed and updated, especially with new prescriptions.

Why not A: Allergies can develop at any time, so the profile must be kept current.

Why not C: Entering an allergy the patient does not have creates false data.

Why not D: The patient is present and is the most direct source to confirm current allergy status.

Exam tactic: NKDA = no known drug allergies. Confirm it is still true.

Q7A patient returns and says, "Since I started this new medicine, I have a rash." What should the technician do?
  1. Involve the pharmacist right away
  2. Tell the patient to stop taking the medicine
  3. Recommend an OTC hydrocortisone cream
  4. Make a note to mention it at the next refill

Answer: A. A possible adverse drug reaction requires the pharmacist's assessment. The pharmacist decides on next steps, such as contacting the prescriber or advising urgent care if severe symptoms are present.

Why not B: Advising a patient to stop a medication is clinical advice.

Why not C: Recommending a treatment is clinical judgment reserved for the pharmacist.

Why not D: Delaying assessment of a possible allergic reaction is unsafe.

Exam tactic: Possible adverse reaction = pharmacist now.

Q8A patient with asthma listed in the profile brings a new prescription for propranolol. Which type of DUR alert does this represent?
  1. Drug-drug
  2. Therapeutic duplication
  3. Drug-allergy
  4. Drug-disease

Answer: D. Propranolol is a nonselective beta blocker that can cause bronchospasm in patients with asthma. A drug that may worsen an existing condition triggers a drug-disease alert.

Why not A: The concern is the patient's asthma, a condition, not another medication.

Why not B: Nothing in the profile shows another beta blocker.

Why not C: Asthma is a disease, not a documented drug allergy.

Exam tactic: Drug + patient's condition = drug-disease alert.

Q9A new prescription for cephalexin is flagged for a patient with a penicillin allergy. Why does this alert appear?
  1. Cephalexin is a penicillin with a different name
  2. Cephalexin contains a sulfonamide group
  3. Possible cross-sensitivity between beta-lactam classes
  4. Cephalexin interacts with all antibiotics in the profile

Answer: C. Penicillins and cephalosporins are both beta-lactam antibiotics, and some patients with a penicillin allergy react to cephalosporins. The pharmacist reviews the type of reaction and decides with the prescriber.

Why not A: Cephalexin is a first-generation cephalosporin, not a penicillin.

Why not B: Cephalexin is not a sulfonamide. The concern is beta-lactam cross-sensitivity.

Why not D: The alert is an allergy alert, not a drug-drug interaction.

Exam tactic: Penicillin allergy + cephalosporin = cross-sensitivity alert for the pharmacist.

Q10Which task requires a pharmacist's professional judgment rather than a technician?
  1. Recommending an OTC cough product to a patient
  2. Entering a patient's new insurance information
  3. Counting tablets and affixing the prescription label
  4. Pulling stock bottles for a prescription order

Answer: A. Recommending an OTC product requires assessing the patient's conditions and other medications, which is clinical judgment reserved for the pharmacist. For example, some decongestants are a concern in hypertension.

Why not B: Entering demographic and insurance data is a routine technician task.

Why not C: Counting and labeling are standard technician tasks, followed by pharmacist verification.

Why not D: Retrieving products for filling is a routine technician task.

Exam tactic: Choosing or recommending therapy = pharmacist. Data, counting, labeling = technician.

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More about the PTCE

PassPulse is an independent exam preparation tool. We are not affiliated with, endorsed by, or sponsored by the Pharmacy Technician Certification Board (PTCB) or the National Healthcareer Association (NHA). Exam, credential and product names mentioned on this page are trademarks of their respective owners and are used only to identify the exams described.

These practice questions are written by PassPulse to reflect the published exam content outline. They are not actual exam questions. Questions, answers and explanations may contain errors or be out of date, and they are for exam study only, not for clinical or professional practice: always check facts against the certifying body's official materials, current standards and your employer's policies. Scores and projections on this page are estimates based on a small number of questions and do not predict your result on the real exam. Area weights come from the official outline as of the date shown; always confirm current exam details with the certifying body.
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